A role for LIM kinase in cancer invasion
- Author(s)
- Yoshioka, K; Foletta, V; Bernard, O; Itoh, K;
- Details
- Publication Year 2003-06-10,Volume 100,Issue #12,Page 7247-7252
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Publication Type
- Journal Article
- Abstract
- In this study, we show that LIM kinase 1 (LIMK1), a critical regulator of actin dynamics, plays a regulatory role in tumor cell invasion. We found that the level and activity of endogenous LIMK1 is increased in invasive breast and prostate cancer cell lines in comparison with less invasive cells. Overexpression of LIMK1 in MCF-7 and in MDA-MB-231 human breast cancer cell lines increased their motility, whereas the specific ROCK and Rho inhibitors Y-27632 and C3, respectively, attenuated this effect. In addition, inhibition of LIMK1 activity in the MDA-MB-231 cells by expression of dominant-negative LIMK1 resulted in decreased motility and formation of osteolytic bone lesions in an animal model of tumor invasion. This study shows an important role for LIMK1 signaling in invasion of cancer, demonstrating its potential as a therapeutic molecular target to decrease metastasis.
- Publisher
- NATL ACAD SCIENCES
- Keywords
- RHO-ASSOCIATED KINASE; HORMONE-RELATED PROTEIN; BREAST-CANCER; TUMOR-CELLS; BONE METASTASIS; BISPHOSPHONATE IBANDRONATE; SERINE/THREONINE KINASE; COFILIN PHOSPHORYLATION; FOCAL ADHESIONS; STRESS FIBERS
- Publisher's Version
- https://doi.org/10.1073/pnas.1232344100
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2003-06-10 12:00:00