Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons

Author(s): Seaman, C; Cooper, HM;
Details: Publication Year 2001-03,Volume 101,Issue #1-2,Page 245-248
Journal Title: MECHANISMS OF DEVELOPMENT
Publication Type: Journal Article
Abstract: The netrin family of axon guidance cues has been shown to play a pivotal role in the guidance of a variety of axon projections during embryonic development, both in the vertebrate and invertebrate, While the guidance potential of netrin-1 has been examined in depth in many regions of the developing mouse brain very little information is available on the expression and activity of netrin-3. Here we show that the netrin-3 protein is present on motor neurons and subpopulations of neurons within sensory and sympathetic ganglia. Moreover. significant levels of netrin-3 protein were found to be associated with the axons projecting from these neurons suggesting a role for netrin-3 in axon pathfinding and fasciculation within the peripheral nervous: system. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
Publisher: ELSEVIER SCIENCE BV
Publisher's Version: https://doi.org/10.1016/S0925-4773(00)00563-3
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2001-03-01 12:00:00