Negative regulators of cytokine signaling
- Author(s)
- Kile, BT; Nicola, NA; Alexander, WS;
- Details
- Publication Year 2001-04,Volume 73,Issue #3,Page 292-298
- Journal Title
- INTERNATIONAL JOURNAL OF HEMATOLOGY
- Publication Type
- Journal Article
- Abstract
- The interaction of a cytokine with its specific cell surface receptor triggers the activation of intracellular signaling pathways that ultimately program the cellular response. Although the specific components and actions of the pathways driving these responses, such as the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway, are relatively well defined, it is becoming clear that important mechanisms exist to restrain these signaling cascades. This review discusses the key biochemical actions and biological roles of the phosphatase SHP-1, the protein inhibitors of activated STATs (PIAS) and the suppressor of cytokine signaling (SOCS) protein family in the negative regulation of cytokine signal transduction. (C) 2001 The Japanese Society of Hematology.
- Publisher
- CARDEN JENNINGS PUBL CO LTD
- Keywords
- TYROSINE-PHOSPHATASE SHP-1; TUMOR-SUPPRESSOR PROTEIN; MICE LACKING SUPPRESSOR; SOCS-BOX MOTIF; SH2 DOMAIN; ERYTHROPOIETIN RECEPTOR; STAT5 ACTIVATION; SH2-CONTAINING PROTEIN; ELONGIN-B; T-CELLS
- Publisher's Version
- https://doi.org/10.1007/BF02981953
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-04-01 12:00:00