Signaling by Type I and II cytokine receptors: ten years after
- Author(s)
- Gadina, M; Hilton, D; Johnston, JA; Morinobu, A; Lighvani, A; Zhou, YJ; Visconti, R; O'Shea, JJ;
- Details
- Publication Year 2001-06,Volume 13,Issue #3,Page 363-373
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Discovered during the past ten years, Janus kinases and signal transducers and activators of transcription have emerged as critical elements in cytokine signaling and immunoregulation. Recently, knockout mice for all the members of these families have been generated, with remarkably specific outcomes. Equally exciting is the discovery of a new class of inhibitors, the suppressor of cytokine signaling family. The phenotypes of mice deficient in these molecules are also striking, underscoring the importance of negative regulation in cytokine signaling.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- SERINE PHOSPHORYLATION; NEGATIVE REGULATION; INTERFERON-GAMMA; TYROSINE KINASE; T-CELLS; TRANSCRIPTIONAL ACTIVATION; PSEUDOKINASE DOMAIN; JANUS KINASES; IMMUNE-SYSTEM; SOCS PROTEINS
- Publisher's Version
- https://doi.org/10.1016/S0952-7915(00)00228-4
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-06-01 12:00:00