Signaling by Type I and II cytokine receptors: ten years after
Details
Publication Year 2001-06,Volume 13,Issue #3,Page 363-373
Journal Title
CURRENT OPINION IN IMMUNOLOGY
Publication Type
Journal Article
Abstract
Discovered during the past ten years, Janus kinases and signal transducers and activators of transcription have emerged as critical elements in cytokine signaling and immunoregulation. Recently, knockout mice for all the members of these families have been generated, with remarkably specific outcomes. Equally exciting is the discovery of a new class of inhibitors, the suppressor of cytokine signaling family. The phenotypes of mice deficient in these molecules are also striking, underscoring the importance of negative regulation in cytokine signaling.
Publisher
CURRENT BIOLOGY LTD
Keywords
SERINE PHOSPHORYLATION; NEGATIVE REGULATION; INTERFERON-GAMMA; TYROSINE KINASE; T-CELLS; TRANSCRIPTIONAL ACTIVATION; PSEUDOKINASE DOMAIN; JANUS KINASES; IMMUNE-SYSTEM; SOCS PROTEINS
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2001-06-01 12:00:00
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