Leukaemia inhibitory factor abrogates Paclitaxel-induced axonal atrophy in the Wistar rat
- Author(s)
- Kilpatrick, TJ; Phan, S; Reardon, K; Lopes, EC; Cheema, SS;
- Details
- Publication Year 2001-08-24,Volume 911,Issue #2,Page 163-167
- Journal Title
- BRAIN RESEARCH
- Publication Type
- Journal Article
- Abstract
- A prominent side effect of Paclitaxel chemotherapy is sensorimotor peripheral neuropathy. Leukaemia inhibitory factor (LIF) supports the survival and regrowth of axotomised sensory and motor neurons and we therefore investigated if systemically administered LIF abrogated Paclitaxel-induced neuropathy. We found that whereas animals administered Paclitaxel alone exhibited a significant decrease in the percentage of large myelinated axons, this reduction was prevented by the co-administration of LIF. (C) 2001 Elsevier Science B.V. All rights reserved.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- TAXOL; NEUROPATHY; DEATH
- Publisher's Version
- https://doi.org/10.1016/S0006-8993(01)02627-0
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-08-24 12:00:00