Assessment of susceptibility of Plasmodium falciparum to chloroquine, quinine, mefloquine, sulfadoxine-pyrimethamine and artemisinin in southern Viet Nam
- Author(s)
- Thanh, NV; Cowman, AF; Hipgrave, D; Kim, TB; Phuc, BQ; Cong, LD; Biggs, BA;
- Details
- Publication Year 2001-09,Volume 95,Issue #5,Page 513-517
- Journal Title
- TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
- Publication Type
- Journal Article
- Abstract
- Resistance to antimalarial chemotherapy is a major concern for malaria control in Viet Nam. In this study undertaken in 1998, 65 patients with uncomplicated Plasmodium falciparum malaria were monitored for 28 days after completion of a 5-day treatment course with artemisinin. Overall 36-9% (24/65) of patients had recurrent parasitaemia during the surveillance period. P. falciparum isolates were tested for sensitivity in vitro to chloroquine, mefloquine, quinine, sulfadoxine-pyrimethamine and results were compared to those from a similar study in 1995, Increased parasite sensitivity to sulfadoxine-pyrimethamine, chloroquine and quinine was demonstrated, with significantly lower mean EC50 and EC99 values in 1998 compared to 1995. Parasite sensitivity to mefloquine did not differ significantly in the 2 surveys. Isolates were also tested for sensitivity in vitro to artemisinin in the 1998 survey. The mean EC50 was 0.03 mu mol/L and the EC99 was 0.94 mu mol/L. Parasite sensitivity to artemisinin will need to be monitored in view of its increasing use in Viet Nam.
- Publisher
- ROYAL SOC TROPICAL MEDICINE
- Keywords
- IN-VITRO SUSCEPTIBILITY; DIHYDROFOLATE-REDUCTASE; DERIVATIVES; ANTIMALARIALS; GENES
- Publisher's Version
- https://doi.org/10.1016/S0035-9203(01)90023-9
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-09-01 12:00:00