"Decisions, decisions ...": beta-catenin-mediated activation of TCF-I and Lef-I influences the fate of developing T cells
- Author(s)
- Wu, L; Strasser, A;
- Details
- Publication Year 2001-09,Volume 2,Issue #9,Page 823-824
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Successful passage through several developmental checkpoints determines whether thymocytes survive, proliferate or differentiate. New data show that Wnt-frizzled-induced activation of TCF-1 or Lef-1, via their coactivator beta -catenin, is critical during TCRB and TCRA gene rearrangement in thymocytes.
- Publisher
- NATURE AMERICA INC
- Keywords
- FADD/MORT1; APOPTOSIS; BCL-2; DIFFERENTIATION; PROLIFERATION; PATHWAYS; MUTANT; MICE
- Publisher's Version
- https://doi.org/10.1038/ni0901-823
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-09-01 12:00:00