Functional analysis of drug resistance in Plasmodium falciparum in the post-genomic era
Author(s)
Cowman, AF;
Details
Publication Year 2001-07,Volume 31,Issue #9,Page 871-878
Journal Title
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Publication Type
Journal Article
Abstract
Malaria has plagued humans throughout recorded history and results in the death of over 2 million people per year. The protozoan parasite Plasmodium falciparum causes the most severe form of malaria in humans. Chemotherapy has become one of the major control strategies for this parasite; however, the development of drug resistance to virtually all of the currently available drugs is causing a crisis in the use and deployment of these compounds for prophylaxis and treatment of this disease. The genome sequence of P. falciparum is providing the informational base for the use of whole-genome strategies such as bioinformatics, microarrays and genetic mapping. These approaches, together with the availability of a high-resolution genome linkage map consisting of hundreds of microsatellite markets and the advanced technologies of transfection and proteomics. will facilitate an integrated approach to address important biological questions. In this review we will discuss strategies to identify novel genes involved in the molecular mechanisms used by the parasite to circumvent the lethal effect of current chemotherapeutic agents. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
HUMAN MALARIA PARASITE; CHROMOSOME SIZE POLYMORPHISMS; THYMIDYLATE SYNTHASE GENE; DIGESTIVE VACUOLAR PH; CHLOROQUINE RESISTANCE; DIHYDROFOLATE-REDUCTASE; PYRIMETHAMINE RESISTANCE; DIHYDROPTEROATE SYNTHASE; MULTIDRUG-RESISTANCE; PFMDR1 GENE
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Creation Date: 2001-07-01 12:00:00
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