Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4

Kile, BT; Viney, EM; Willson, TA; Brodnicki, TC; Cancilla, MR; Herlihy, AS; Croker, BA; Baca, M; Nicola, NA; Hilton, DJ; Alexander, WS

Author(s): Kile, BT; Viney, EM; Willson, TA; Brodnicki, TC; Cancilla, MR; Herlihy, AS; Croker, BA; Baca, M; Nicola, NA; Hilton, DJ; Alexander, WS;
Details: Publication Year 2000-11-27,Volume 258,Issue #1-2,Page 31-41
Journal Title: GENE
Publication Type: Journal Article
Abstract: Members of the suppressor of cytokine signalling (SOCS) family of proteins have been shown to inhibit cytokine signalling via direct interactions with JAK kinases or activated cytokine receptors. In addition to their novel amino-terminal regions and SH2 domains that mediate these interactions, the SOCS proteins also contain carboxy-terminal regions of homology called the SOCS box. The SOCS box serves to couple SOCS proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Several other families of proteins also contain SOCS boxes but differ from the SOCS proteins in the type of domain or motif they contain upstream of the SOCS box. We report here the cloning, characterization, mapping and expression analysis of four members of the ankyrin repeat and SOCS box-containing (Asb) protein family. (C) 2000 Elsevier Science B.V. All rights reserved.
Publisher: ELSEVIER SCIENCE BV
Keywords: TUMOR-SUPPRESSOR P16(INK4A); SIGNAL-TRANSDUCTION; CRYSTAL-STRUCTURE; DOMAIN; MOTIF; REQUIREMENT; MECHANISMS; P18(INK4C); INHIBITION; MUTATIONS
Publisher's Version: https://doi.org/10.1016/S0378-1119(00)00402-9
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2000-11-27 12:00:00