Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit

Author(s): Huang, D; Cancilla, MR; Morahan, G;
Details: Publication Year 2000-12,Volume 1,Issue #8,Page 515-520
Journal Title: GENES AND IMMUNITY
Publication Type: Journal Article
Abstract: Owing to the importance of interleukin (IL)-12 in regulating immune responses, we have determined the complete genomic sequence and organization of the gene encoding its p40 subunit. The genomic sequence was determined and was compared to cDNA sequences to derive exon/intron boundaries. Unusually, both the first and last of the eight exons of this gene are not translated An extensive search identified several polymorphisms in IL-12p40, including repeat elements in introns 2 and 4 and a polymorphic Taql site in the 3UTR. However, no polymorphisms were found which could result in amino acid substitutions. This finding places constraints on any preferential involvement of alleles of IL-12p40 in contributing to autoimmune, inflammatory or infectious diseases.
Publisher: NATURE PUBLISHING GROUP
Keywords: CELL STIMULATORY FACTOR; LINKAGE ANALYSIS; RECEPTOR; LOCALIZATION; CYTOKINE
Publisher's Version: https://doi.org/10.1038/sj.gene.6363720
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2000-12-01 12:00:00