Antigen-specific therapy for autoimmune disease
- Author(s)
- Harrison, LC; Hafler, DA;
- Details
- Publication Year 2000-12,Volume 12,Issue #6,Page 704-711
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The application of self-antigens as therapeutic tools is validated in inbred animal models of autoimmune disease. Mechanisms of antigen-induced tolerance (apoptosis, anergy, regulatory T cells and immune deviation) are being clarified in relation to the properties-of antigens and the modes and routes of their delivery. Mucosa-mediated tolerance remains the predominant mode of antigen-specific therapy but awaits demonstration of clinical efficacy in human autoimmune disease.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- MYELIN BASIC-PROTEIN; ALTERED PEPTIDE LIGANDS; T-CELL ACTIVATION; NONOBESE DIABETIC MICE; GROWTH-FACTOR-BETA; ORAL TOLERANCE; NOD MICE; TRANSGENIC EXPRESSION; BYSTANDER SUPPRESSION; IMMUNE DEVIATION
- Publisher's Version
- https://doi.org/10.1016/S0952-7915(00)00166-7
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-12-01 12:00:00