Cross-presentation, dendrttic cells, tolerance and immunity
- Author(s)
- Heath, WR; Carbone, FR;
- Journal Title
- ANNUAL REVIEW OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.
- Publisher
- ANNUAL REVIEWS
- Keywords
- MHC CLASS-I; ANTIGEN-PRESENTING CELLS; CYTOTOXIC T-LYMPHOCYTES; EXOGENOUS SOLUBLE-ANTIGEN; MARROW-DERIVED CELLS; SHOCK-PROTEIN GP96; DENDRITIC CELLS; APOPTOTIC CELLS; CD40 LIGAND; REQUIRES PRESENTATION
- Publisher's Version
- https://doi.org/10.1146/annurev.immunol.19.1.47
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-01-01 12:00:00