Presentation of antigens by MHC class II molecules: getting the most out of them
- Author(s)
- Villadangos, JA;
- Details
- Publication Year 2001-09,Volume 38,Issue #5,Page 329-346
- Journal Title
- MOLECULAR IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The function of MHC class II molecules is to bind peptides derived from antigens that access the endocytic route or antigen presenting cells and display them on the plasma membrane for recognition by CD4' T cells. Formation or the MHC II-peptide complexes entails the confluence of the antigens and the MHC II molecules in the same compartments of the endocytic route. There, both the antigens and the MHC II molecules undergo a series of orchestrated changes that involve proteases, other hydrolases and chaperones, culminating in the generation of a wide repertoire of MHC II-peptide combinations. All the events that lead to formation of MHC II-peptide complexes show a considerable degree of flexibility; this lack of strict rules is advantageous in that it provides T cells with the maximum amount of information, ensuring that pathogens do not go undetected. (C) 2001 Published by Elsevier Science Ltd.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- COMPLEX CLASS-II; HLA-DR MOLECULES; IMMATURE DENDRITIC CELLS; EGG-WHITE LYSOZYME; INVARIANT CHAIN DEGRADATION; NEWLY SYNTHESIZED PROTEINS; THIOL REDUCTASE GILT; HUMAN CATHEPSIN-F; LOADED CLASS-II; IN-VIVO
- Publisher's Version
- https://doi.org/10.1016/S0161-5890(01)00069-4
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-09-01 12:00:00