Life-or-death decisions by the Bcl-2 protein family
- Details
- Publication Year 2001-01,Volume 26,Issue #1,Page 61-66
- Journal Title
- TRENDS IN BIOCHEMICAL SCIENCES
- Publication Type
- Journal Article
- Abstract
- In response to intracellular damage and certain physiological cues, cells enter the suicide program termed apoptosis, executed by proteases called caspases. Commitment to apoptosis is typically governed by opposing factions of the Bcl-2 family of cytoplasmic proteins, Initiation of the proteolytic cascade requires assembly of certain caspase precursors on a scaffold protein, and the Bcl-2 family determines whether this complex can form. Its pro-survival members can act by sequestering the scaffold protein and/or by preventing the release of apoptogenic molecules from organelles such as mitochondria. Pro-apoptotic family members act as sentinels for cellular damage: cytotoxic signals induce their translocation to the organelles where they bind to their pro-survival relatives, promote organelle damage and trigger apoptosis.
- Publisher
- ELSEVIER SCIENCE LONDON
- Keywords
- PROGRAMMED CELL-DEATH; OUTER MITOCHONDRIAL-MEMBRANE; CYTOCHROME-C RELEASE; INTRACELLULAR-LOCALIZATION; CASPASE ACTIVATION; DEFICIENT MICE; BH3 DOMAIN; APOPTOSIS; BAX; SURVIVAL
- Publisher's Version
- https://doi.org/10.1016/S0968-0004(00)01740-0
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-01-01 12:00:00