Inhibition of adhesion of Plasmodium falciparum-infected erythrocytes by structurally defined hyaluronic acid dodecasaccharides

Author(s): Chai, WG; Beeson, JG; Kogelberg, H; Brown, GV; Lawson, AM;
Details: Publication Year 2001-01,Volume 69,Issue #1,Page 420-425
Journal Title: INFECTION AND IMMUNITY
Publication Type: Journal Article
Abstract: We recently reported that Plasmodium falciparum-infected erythrocytes (IRBCs) can adhere to hyaluronic acid (HA), which appears to be a receptor, in addition to chondroitin sulfate A (CSA), for parasite sequestration in the placenta. Further investigations of the nature and specificity of this interaction indicate that HA oligosaccharide fragments competitively inhibit parasite adhesion to immobilized purified HA in a size-dependent manner, with dodecasaccharides being the minimum size for maximum inhibition. Rigorously purified and structurally defined HA dodecasaccharides, free of contamination by CSA or other glycosaminoglycans, effectively inhibited IRBC adhesion to HA but not CSA, providing compelling evidence of a specific interaction between IRBCs and HA.
Publisher: AMER SOC MICROBIOLOGY
Keywords: CHONDROITIN SULFATE-A; MEMBRANE PROTEIN-1; MASS-SPECTROMETRY; MALARIA; PLACENTA; NMR; OLIGOSACCHARIDES; HEXASACCHARIDES; CYTOADHERENCE; SACCHARIDES
Publisher's Version: https://doi.org/10.1128/IAI.69.1.420-425.2001
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2001-01-01 12:00:00