Lineage commitment and maturation induction in normal and leukemic preprogenitor cells
- Author(s)
- Metcalf, D; Laabi, Y;
- Journal Title
- HEMATOPOIETIC STEM CELLS 2000 BASIC AND CLINICAL SCIENCES
- Publication Type
- S
- Abstract
- Analysis of the critical cellular processes of self-generation, commitment, and maturation induction ideally requires the use of clonal cultures using cells with a capacity to undergo all three processes. Preprogenitor cells from normal mouse marrow are proving useful cells for such studies. Cells of a newly established cloned leukemic cell line, the GB2, are providing a useful analogous leukemic system because GB2 cells form stratified subpopulations of clonogenic cells able to be clonally analyzed in vitro in which self-renewal is demonstrable, but in which near-normal maturation can be induced by a wide range of hematopoietic regulators.
- Publisher
- NEW YORK ACAD SCIENCES
- Keywords
- COLONY-STIMULATING FACTOR; PRE-PROGENITOR CELLS; TRANSCRIPTION FACTORS; STEM-CELLS; IN-VIVO; B-CELL; G-CSF; DIFFERENTIATION; HEMATOPOIESIS; THROMBOPOIETIN
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- Refer to copyright notice on published article.
Creation Date: 2001-01-01 12:00:00