Cytotoxicity of paclitaxel or cisplatin on carcinoma cell lines is not inhibited by leukemia inhibitory factor (LIF)
- Author(s)
- O'Flaherty, E; Cook, W; Boyd, J; Grant, SL; Kurek, J; Begley, CG;
- Details
- Publication Year 2002,Volume 20,Issue #3,Page 141-145
- Journal Title
- GROWTH FACTORS
- Publication Type
- Journal Article
- Abstract
- We have established a reliable, reproducible and objective growth assay to measure whether leukemia inhibitory factor (LIF) was able to protect tumour-derived cell lines from toxic effects of the chemotherapy agents, cisplatin and paclitaxel. Using this assay, we demonstrated that LIF did not alter the cytotoxic action of these drugs, on a panel of seven cancer cell lines. This was not because of the inactivity of the LIF or because the cell lines did not express components of the LIF receptor. These findings suggest that the potential clinical use of LIF, as a neuroprotective agent, in conjunction with chemotherapy will not interfere with the anti-tumour treatment.
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- GROWTH; DIFFERENTIATION; EXPRESSION; GP130; CHAIN
- Publisher's Version
- https://doi.org/10.1080/0897719021000032038
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-01-01 12:00:00