Cross-presentation of antigens by dendritic cells
- Author(s)
- Belz, GT; Carbone, FR; Heath, WR;
- Details
- Publication Year 2002-01-01,Volume 22,Issue #5-6,Page 439-448
- Journal Title
- CRITICAL REVIEWS IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- T lymphocytes recognize antigen presented on the surface of antigen-presenting cells by MHC class I and class 11 molecules. Classically, MHC class I molecules present self- or pathogen-derived antigens that are synthesized within the cell, whereas exogenous antigens derived via endocytic uptake are loaded onto MHC class II molecules for presentation to CD4(+) T cells. It is becoming increasingly clear that some dendritic cells are also specialized to process exogenous antigens into the MHC class I pathway for presentation to CD8(+) T cells. This process is known as cross-presentation. It provides a mechanism that can drive dendritic cells to generate either tolerance to self-antigens or immunity to pathogens. The cells responsible for, and mechanisms underlying, this decision between tolerance and immunity via cross-presentation has become the focus of intense study to determine how various dendritic cell subsets effect the different outcomes.
- Publisher
- BEGELL HOUSE INC
- Keywords
- MHC CLASS-I; CD8(+) T-CELLS; SHOCK-PROTEIN GP96; PRESENT EXOGENOUS ANTIGENS; HERPES-SIMPLEX VIRUS; MOUSE LYMPH-NODES; SOLUBLE-ANTIGEN; APOPTOTIC CELLS; CUTTING EDGE; SURFACE PHENOTYPE
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-01-01 12:00:00