The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes
Details
Publication Year 2002-04-01, Volume 168, Issue #7, Page 3376-3386
Journal Title
JOURNAL OF IMMUNOLOGY
Publication Type
Journal Article
Abstract
We have defined roles for the hemopoietic-specific Rho guanosine triphosphatase, Rac2, in B lymphocyte development and function through examination of rac2(-/-) mice. Rac2-deficient mice displayed peripheral blood B lymphocytosis and marked reductions in peritoneal cavity B-la lymphocytes, marginal zone B lymphocytes, and IgM-secreting plasma cells as well as reduced concentrations of serum IgM and IgA. The rac2(-/-) B lymphocytes exhibited reduced calcium flux following coligation of B cell AgR and CD19 and reduced chemotaxis in chemokine gradients. T cell-independent responses to DNP-dextran were of reduced magnitude, but normal kinetics, in rac2(-/-) mice, while T-dependent responses to nitrophenyl-keyhole limpet hemocyanin were subtly abnormal. Rac2 is therefore an essential element in regulating B lymphocyte functions and maintaining B lymphocyte populations in vivo.
Publisher
AMER ASSOC IMMUNOLOGISTS
Keywords
PRIMARY IMMUNE-RESPONSE; T-CELL; SIGNAL-TRANSDUCTION; CHEMOKINE RECEPTOR; NEGATIVE REGULATOR; POSITIVE SELECTION; GERMINAL-CENTERS; MICE; CD19; VAV
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Refer to copyright notice on published article.


Creation Date: 2002-04-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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