Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland
- Author(s)
- Zammit, DJ; Berzins, SP; Gill, JW; Randle-Barrett, ES; Barnett, L; Koentgen, F; Lambert, GW; Harvey, RP; Boyd, FL; Classon, BJ;
- Details
- Publication Year 2002-02-01,Volume 22,Issue #3,Page 946-952
- Journal Title
- MOLECULAR AND CELLULAR BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Thymic shared antigen 1 (TSA-1) is a Plasma membrane protein of the Ly-6 superfamily expressed on thymocytes, thymic stromal cells, and other cells of the hematopoietic system. TSA-1 is also expressed in other nonhematopoietic tissues, in particular, embryonic and adult adrenal glands. To address the function of TSA-1, we generated mutant mice in which TSA-1 expression was inactivated by, gene targeting. Here we show that deletion of both TSA-1 alleles results in abnormal adrenal gland development and midgestational lethality due to cardiac abnormalities. We also report that TSA-1-deficient adrenal glands have significantly reduced levels of the catecholamines noradrenaline and adrenaline. We conclude that TSA-1 is required for normal embryonic development but that deletion of its expression does not obviously impair lymphoid development.
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- STEM-CELL ANTIGEN-2; MOUSE FETAL DEVELOPMENT; TARGETED DISRUPTION; PRECURSOR CELLS; T-LYMPHOCYTES; ORGAN-CULTURE; EXPRESSION; ADULT; THYMOCYTES; FAMILY
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Creation Date: 2002-02-01 12:00:00