Cutting edge: Precursor frequency affects the helper dependence of cytotoxic T cells
- Author(s)
- Mintern, JD; Davey, GM; Belz, GT; Carbone, FR; Heath, WR;
- Details
- Publication Year 2002-02-01,Volume 168,Issue #3,Page 977-980
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Generation of CTL immunity often depends on the availability of CD4 T cell help. In this report, we show that CTL responses induced by cross-priming can be converted from CD4-dependent to CD4-independent by increasing the frequency of CTL precursors. In the absence of CD4 T cells, high numbers of CTL precursors were able to expand in number and become effector CTL. The ability of high frequencies of CD8 T cells to override help was not due to their ability to signal CD40 via expression of CD154. These findings suggest that when precursor frequencies are high, priming of CD8 T cell responses may not require CD4 T cell help.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- CLASS-I; POSITIVE SELECTION; CD8+ CELLS; LYMPHOCYTES; INVIVO; RESPONSES; ACTIVATION; GENERATION; INDUCTION; PEPTIDES
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-02-01 12:00:00