Immunobiology of liver dendritic cells
- Author(s)
- Thomson, AW; O'Connell, PJ; Steptoe, RJ; Lu, L;
- Details
- Publication Year 2002-02,Volume 80,Issue #1,Page 65-73
- Journal Title
- IMMUNOLOGY AND CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Dendritic cells (DC) are rare, bone marrow-derived antigen-presenting cells that play a critical role in the induction and regulation of immune reactivity. In this article, we review the identification and characterization of liver DC, their ontogenic development, in vivo mobilization and population dynamics. In addition, we discuss the functions of DC isolated from liver tissue or celiac lymph, or propagated in vitro from liver-resident haemopoietic stem/progenitor cells. Evidence concerning the role of DC in viral hepatitis. liver tumours, autoimmune liver diseases, granulomatous inflammation and the outcome of liver transplantation is also discussed.
- Publisher
- BLACKWELL PUBLISHING ASIA
- Keywords
- PRIMARY BILIARY-CIRRHOSIS; COLONY-STIMULATING FACTOR; ANTIGEN-PRESENTING CELLS; RECIPIENT LYMPHOID-TISSUE; VIRUS-TRANSGENIC MICE; MHC CLASS-II; MOUSE-LIVER; RAT-LIVER; CYTOKINE PRODUCTION; IN-VITRO
- Publisher's Version
- https://doi.org/10.1046/j.0818-9641.2001.01058.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-02-01 12:00:00