Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development
- Author(s)
- Cowman, AF; Baldi, DL; Duraisingh, M; Healer, J; Mills, KE; O'Connell, RA; Thompson, J; Triglia, T; Wickham, ME; Crabb, BS;
- Details
- Publication Year 2002-01-29,Volume 357,Issue #1417,Page 25-33
- Journal Title
- PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
- Publication Type
- Journal Article
- Abstract
- Malaria is a major human health problem and is responsible for over 2 million deaths per year. It is caused by a number of species of the genus Plasmodium, and Plasmodium falciparum is the causative agent of the most lethal form. Consequently, the development of a vaccine against this parasite is a priority. There are a number of stages of the parasite life cycle that are being targeted for the development of vaccines. Important candidate antigens include proteins on the surface of the asexual merozoite stage, the form that invades the host erythrocyte. The development of methods to manipulate the genome of Plasmodium species has enabled the construction of gain-of-function and loss-of-function mutants and provided new strategies to analyse the role of parasite proteins. This has provided new information on the role of merozoite antigens in erythrocyte invasion and also allows new approaches to address their potential as vaccine candidates.
- Publisher
- ROYAL SOC LONDON
- Keywords
- APICAL MEMBRANE ANTIGEN; INHIBITORY MONOCLONAL-ANTIBODIES; MALARIA PARASITE INVASION; C-TERMINAL FRAGMENT; SURFACE PROTEIN-1; RHOPTRY-PROTEIN; RECEPTOR HETEROGENEITY; ENDOPLASMIC-RETICULUM; SEQUENCE-ANALYSIS; BINDING-PROTEINS
- Publisher's Version
- https://doi.org/10.1098/rstb.2001.1010
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-01-29 12:00:00