Resistance to antiparasitic drugs: the role of molecular diagnosis
- Author(s)
- Sangster, N; Batterham, P; Chapman, HD; Duraisingh, M; Le Jambre, L; Shirley, M; Upcroft, J; Upcroft, P;
- Details
- Publication Year 2002-05,Volume 32,Issue #5,Page 637-653
- Journal Title
- INTERNATIONAL JOURNAL FOR PARASITOLOGY
- Publication Type
- Journal Article
- Abstract
- Chemotherapy is central to the control of many parasite infections of both medical and veterinary importance. However, control has been compromised by the emergence of drug resistance in several important parasite species. Such parasites cover a broad phylogenetic range and include protozoa, helminths and arthropods. In order to achieve effective parasite control in the future, the recognition and diagnosis of resistance will be crucial. This demand for early, accurate diagnosis of resistance to specific drugs in different parasite species can potentially be met by modern molecular techniques. This paper summarises the resistance status of a range of important parasites and reviews the available molecular techniques for resistance diagnosis. Opportunities for applying successes in some species to other species where resistance is less well understood are explored. The practical application of molecular techniques and the impact of the technology on improving parasite control are discussed. (C) 2002 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- POLYMERASE CHAIN-REACTION; ETHYL METHANESULFONATE MUTAGENESIS; FALCIPARUM DIHYDROFOLATE-REDUCTASE; DROSOPHILA-MELANOGASTER DIPTERA; DIHYDROPTEROATE SYNTHETASE GENE; LUCILIA-CUPRINA DIPTERA; BETA-TUBULIN ISOTYPE-1; PLASMODIUM-FALCIPARUM; ANTHELMINTIC RESISTANCE; HAEMONCHUS-CONTORTUS
- Publisher's Version
- https://doi.org/10.1016/S0020-7519(01)00365-4
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-05-01 12:00:00