Neuraminidase inhibitors as antivirals
- Author(s)
- Colman, PM;
- Journal Title
- VACCINE
- Publication Type
- Journal Article
- Abstract
- The description of the three-dimensional structure of the influenza virus neuraminidase in 1983 opened a new phase in the search for inhibitors of the enzyme. Two compounds in late development (February 1999) have similar levels of potency against influenza A viruses, different routes of administration and, surprisingly, different resistance profiles both in vitro and in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- INFLUENZA-VIRUS NEURAMINIDASE; A VIRUS; ACTIVE-SITE; SIALIC-ACID; IN-VITRO; 4-GUANIDINO-NEU5AC2EN; DESIGN; SENSITIVITY; GENERATION; SIALIDASES
- Publisher's Version
- https://doi.org/10.1016/S0264-410X(02)00132-9
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-05-15 12:00:00