Suppressors of cytokine signalling (SOCS) in the immune system
- Author(s)
- Alexander, WS;
- Details
- Publication Year 2002-06,Volume 2,Issue #6,Page 410-416
- Journal Title
- NATURE REVIEWS IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The suppressors of cytokine signalling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the immune system, The SOCS proteins seem to regulate signal transduction by combining direct inhibitory interactions with cytokine receptors and signalling proteins with a generic mechanism of targeting associated proteins for degradation. Evidence is emerging for the involvement of SOCS proteins in diseases of the human immune system, which raises the possibility that therapeutic strategies that are based on the manipulation of SOCS activity might be of clinical benefit.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- STAT INHIBITOR-1 (SSI-1)/SUPPRESSOR; COLONY-STIMULATING FACTOR; MICE LACKING SUPPRESSOR; PERIPHERAL-BLOOD CELLS; INTERFERON-GAMMA; NEGATIVE REGULATION; IN-VIVO; SH2-CONTAINING PROTEIN; IFN-GAMMA; T-CELLS
- Publisher's Version
- https://doi.org/10.1038/nri818
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-06-01 12:00:00