gamma delta T cells: Functional plasticity and heterogeneity
- Author(s)
- Carding, SR; Egan, PJ;
- Details
- Publication Year 2002-05,Volume 2,Issue #5,Page 336-345
- Journal Title
- NATURE REVIEWS IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- gammadelta T cells remain an enigma. They are capable of generating more unique antigen receptors than alphabeta T cells and B cells combined, yet their repertoire of antigen receptors is dominated by specific subsets that recognize a limited number of antigens. A variety of sometimes conflicting effector functions have been ascribed to them, yet their biological function(s) remains unclear. On the basis of studies of gammadelta T cells in infectious and autoimmune diseases, we argue that gammadelta T cells perform different functions according to their tissue distribution, antigen-receptor structure and local microenvironment; we also discuss how and at what stage of the immune response they become actuated.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- STAPHYLOCOCCAL ENTEROTOXIN-A; COLLAGEN-INDUCED ARTHRITIS; ALPHA-BETA; LYMPHOCYTES-T; IN-VIVO; INTRAEPITHELIAL LYMPHOCYTES; LISTERIA-MONOCYTOGENES; PULMONARY TUBERCULOSIS; NONPEPTIDE ANTIGENS; BACTERIAL-INFECTION
- Publisher's Version
- https://doi.org/10.1038/nri.797
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-05-01 12:00:00