BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death
- Author(s)
- Bouillet, P; Strasser, A;
- Details
- Publication Year 2002-04-15,Volume 115,Issue #8,Page 1567-1574
- Journal Title
- JOURNAL OF CELL SCIENCE
- Publication Type
- Journal Article
- Abstract
- The BH3-only members of the Bcl-2 protein family, are essential initiators of programmed cell death and are required for apoptosis induced by cytotoxic stimuli. These proteins have evolved to recognise distinct forms of cell stress. In response, they unleash the apoptotic cascade by inactivating the protective function of the pro-survival members of the Bcl-2 family and by activating the Bax/Bak-like pro-apoptotic family members.
- Publisher
- COMPANY OF BIOLOGISTS LTD
- Keywords
- CYTOCHROME-C RELEASE; PERMEABILITY TRANSITION PORE; OUTER MITOCHONDRIAL-MEMBRANE; IN-VIVO; X-L; POLYCYSTIC KIDNEY; SURVIVAL SIGNALS; INDUCE APOPTOSIS; TRANSGENIC MICE; LYMPHOID-CELLS
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-04-15 12:00:00