No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
- Author(s)
- Levinson, DF; Holmans, PA; Laurent, C; Riley, B; Pulver, AE; Gejman, PV; Schwab, SG; Williams, NM; Owen, MJ; Wildenauer, DB; Sanders, AR; Nestadt, G; Mowry, BJ; Wormley, B; Bauche, S; Soubigou, S; Ribble, R; Nertney, DA; Liang, KY; Martinolich, L; Maier, W; Norton, N; Williams, H; Albus, M; Carpenter, EB; deMarchi, N; Ewen-White, KR; Walsh, D; Jay, M; Deleuze, JF; O'Neill, FA; Papadimitriou, G; Weilbaecher, A; Lerer, B; O'Donovan, MC; Dikeos, D; Silverman, JM; Kendler, KS; Mallet, J; Crowe, RR; Walters, M;
- Details
- Publication Year 2002-04-26,Volume 296,Issue #5568,Page 739-741
- Journal Title
- SCIENCE
- Publication Type
- Journal Article
- Abstract
- Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Keywords
- SUSCEPTIBILITY LOCI; LINKAGE ANALYSIS; GENOME SCAN; GENES; 6Q
- Publisher's Version
- https://doi.org/10.1126/science.1069914
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- Refer to copyright notice on published article.
Creation Date: 2002-04-26 12:00:00