The SOCS box: a tale of destruction and degradation
- Author(s)
- Kile, BT; Schulman, BA; Alexander, WS; Nicola, NA; Martin, HME; Hilton, DJ;
- Details
- Publication Year 2002-05,Volume 27,Issue #5,Page 235-241
- Journal Title
- TRENDS IN BIOCHEMICAL SCIENCES
- Publication Type
- Journal Article
- Abstract
- Although initially identified in the suppressor of cytokine signaling (SOCS) family of proteins, the C-terminal SOCS box has now been identified in more than 40 proteins in nine different families. Growing evidence suggests that the SOCS box, similar to the F-box, acts as abridge between specific substrate-binding do m a ins and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS proteins regulate protein turnover by targeting proteins for polyubiquitination and, therefore, for proteasome-mediated degradation.
- Publisher
- ELSEVIER SCIENCE LONDON
- Keywords
- TUMOR-SUPPRESSOR PROTEIN; MICE LACKING SUPPRESSOR; HIPPEL-LINDAU PROTEIN; RNA-POLYMERASE-II; CYTOKINE SIGNALING-1; UBIQUITIN LIGASE; DEPENDENT PROTEOLYSIS; MEDIATED DEGRADATION; KINASE-ACTIVITY; GENE-PRODUCT
- Publisher's Version
- https://doi.org/10.1016/S0968-0004(02)02085-6
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-05-01 12:00:00