Update on HER-2 as a target for cancer therapy - Intracellular signaling pathways of ErbB2/HER-2 and family members

Author(s): Olayioye, MA;
Details: Publication Year 2001-10,Volume 3,Issue #6,Page 385-389
Journal Title: BREAST CANCER RESEARCH
Publication Type: Journal Article
Abstract: ErbB (also termed HER) receptors are expressed in various tissues of epithelial, mesenchymal and neuronal origin, in which they are involved in the control of diverse biological processes such as proliferation, differentiation, migration and apoptosis. Furthermore, their deregulated expression has been implicated in many types of human cancers and is associated with poor clinical prognosis. Owing to the importance of ErbB proteins in both development and cellular transformation, a lot of attention has been drawn to the intracellular signals initiated by the engagement of this family of receptor tyrosine kinases. This review will focus on the membrane proximal events triggered by the ErbB receptor network and will address questions of how receptor heterodimerization may contribute to signal specification and diversification.
Publisher: BIOMED CENTRAL LTD
Keywords: EPIDERMAL GROWTH-FACTOR; NEU DIFFERENTIATION FACTOR; RECEPTOR TYROSINE KINASES; ERBB RECEPTORS; SRC; TRANSFORMATION; ACTIVATION; DISTINCT; SITES; PHOSPHORYLATION
Publisher's Version: https://doi.org/10.1186/bcr327
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2001-10-01 12:00:00