Cross-presentation in viral immunity and self-tolerance
- Author(s)
- Heath, WR; Carbone, FR;
- Details
- Publication Year 2001-11,Volume 1,Issue #2,Page 126-134
- Journal Title
- NATURE REVIEWS IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- T lymphocytes recognize peptide antigens presented by class I and class II molecules encoded by the major histocompatibility complex (MHC). Classical antigen-presentation studies showed that MHC class I molecules present peptides derived from proteins synthesized within the cell, whereas MHC class II molecules present exogenous proteins captured from the environment. Emerging evidence indicates, however, that dendritic cells have a specialized capacity to process exogenous antigens into the MHC class I pathway. This function, known as cross-presentation, provides the immune system with an important mechanism for generating immunity to viruses and tolerance to self.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- ANTIGEN-PRESENTING CELLS; MHC CLASS-I; CD8(+) T-CELLS; PERIPHERALLY EXPRESSED ANTIGENS; HUMAN DENDRITIC CELLS; HERPES-SIMPLEX VIRUS; TOXIC LYMPHOCYTES-T; EXOGENOUS ANTIGEN; CUTTING EDGE; REQUIRES PRESENTATION
- Publisher's Version
- https://doi.org/10.1038/35100512
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-11-01 12:00:00