Neutralization of interferon-gamma in neonatal SOCS1(-/-) mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease
- Author(s)
- Bullen, DVR; Darwiche, R; Metcalf, D; Handman, E; Alexander, WS;
- Details
- Publication Year 2001-09,Volume 104,Issue #1,Page 92-98
- Journal Title
- IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Mice lacking the suppressor of cytokine signalling-1 (SOCS1) die within weeks of birth with extensive fatty degeneration of the liver, consistent with acute hepatic toxicity to interferon-gamma (IFN-gamma), and inflammation of multiple organs. We show here that treatment for 1 week from birth with neutralizing antibody to IFN-gamma rescues SOCS1(-/-) mice from lethal liver disease but the mice subsequently succumb to chronic inflammatory lesions characterized by T-lymphocyte infiltration of skeletal muscle, pancreas, lung, liver and skin. Elevated blood levels of eosinophils, neutrophils and platelets were also observed and the thymic lymphocyte population was depleted of CD4(+) CD8(+) T cells and showed a reduced CD4: CD8 ratio. All T-cell populations in thymus, spleen and lymph node exhibited an increased proportion of cells bearing the activation marker CD44. These data suggest an important role for SOCS1 in T-lymphocyte regulation.
- Publisher
- BLACKWELL SCIENCE LTD
- Keywords
- CYTOKINE; INHIBITOR; PROTEIN; LACKING
- Publisher's Version
- https://doi.org/10.1046/j.1365-2567.2001.01294.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-09-01 12:00:00