Plasmacytoid monocytes/T cells: a dendritic cell lineage?
- Author(s)
- Galibert, L; Maliszewski, CR; Vandenabeele, S;
- Details
- Publication Year 2001-10,Volume 13,Issue #5,Page 283-289
- Journal Title
- SEMINARS IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Plasmacytoid monocytes/T cells were first described in 1958, yet their origin and function have remained enigmatic. Recently a series of publications brought these cells to the forefront of immunological research. Indeed, plasmacytoid monocytes/T-cells contain natural type-I interferon producing cells and can differentiate in vitro into dendritic cells (DC). It has been proposed that plasmacytoid monocytes/T-cells represent a distinct lineage of cells whose fate it is to differentiate into dendritic cells. Herein we will review recent advances in our understanding of plasmacytoid monocytes/T cells and highlight arguments in favor or against this lineage hypothesis. We propose that plasmacytoid monocytes/T cells represent a composite group of both myeloid and lymphoid early-committed cells that are characterized by their ability to differentiate in vitro into DC. (C) 2001 Academic Press.
- Publisher
- ACADEMIC PRESS LTD
- Keywords
- HUMAN PERIPHERAL-BLOOD; ALPHA PRODUCING CELLS; T-CELLS; IN-VIVO; MYELOPROLIFERATIVE DISORDERS; ADAPTIVE IMMUNITY; LYMPHOMA; SUBSETS; LEUKEMIA; ORIGIN
- Publisher's Version
- https://doi.org/10.1006/smim.2001.0324
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2001-10-01 12:00:00