Axon guidance receptors direct growth cone pathfinding: rivalry at the leading edge
- Author(s)
- Cooper, HM;
- Details
- Publication Year 2002-01-01,Volume 46,Issue #4,Page 621-631
- Journal Title
- INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- One of the earliest steps in the development of the central and peripheral nervous systems is the initiation of axon outgrowth from newly born neurons. Nascent axons then navigate towards their specific targets to establish the intricate network of axon projections found within the mature central nervous system. In doing so, the projecting axons must continually reassess their spatial environment and accurately select the correct pathways among the maze of possible routes. A variety of molecular navigational systems governing axon pathfinding have now been identified. Understanding how these individual molecular guidance systems operate at the level of a single axon, and, how these different systems work in concert to initiate and steer axonal migration is a major goal in developmental neurobiology.
- Publisher
- U B C PRESS
- Keywords
- PERIPHERAL-NERVE PROJECTION; NEURONAL MIGRATION; CNS MIDLINE; C-ELEGANS; SECRETED SEMAPHORINS; NETRIN RECEPTORS; EPHB RECEPTORS; SLIT PROTEINS; DCC; DROSOPHILA
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2002-01-01 12:00:00