The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer
Details
Publication Year 2001-12-04, Volume 98, Issue #25, Page 14452-14457
Journal Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publication Type
Journal Article
Abstract
LM04 belongs to a family of LIM-only transcriptional regulators, the first two members of which are oncoproteins in acute T cell leukemia. We have explored a role for LM04, initially described as a human breast tumor autoantigen, in developing mammary epithelium and breast oncogenesis. Lmo4 was expressed predominantly in the lobuloalveoli of the mammary gland during pregnancy. Consistent with a role in proliferation, forced expression of this gene inhibited differentiation of mammary epithelial cells. Overexpression of LM04 mRNA was observed in 5 of 10 human breast cancer cell lines. Moreover, in situ hybridization analysis of 177 primary invasive breast carcinomas revealed overexpression of LM04 in 56% of specimens. immunohistochemistry confirmed overexpression in a high percentage (62%) of tumors. These studies imply a role for LM04 in maintaining proliferation of mammary epithelium and suggest that deregulation of this gene may contribute to breast tumorigenesis.
Publisher
NATL ACAD SCIENCES
Keywords
COMPARATIVE GENOMIC HYBRIDIZATION; COPY NUMBER; ERYTHROID DEVELOPMENT; HOMEODOMAIN PROTEINS; TRANSGENIC MICE; LEUKEMIA; TRANSLOCATIONS; IDENTIFICATION; AMPLIFICATION; EXPRESSION
Rights Notice
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Creation Date: 2001-12-04 12:00:00
Last Modified: 0001-01-01 12:00:00
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