Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

Author(s): Sibley, CH; Hyde, JE; Sims, PFG; Plowe, CV; Kublin, JG; Mberu, EK; Cowman, AF; Winstanley, PA; Watkins, WM; Nzila, AM;
Details: Publication Year 2001-12,Volume 17,Issue #12,Page 582-588
Journal Title: TRENDS IN PARASITOLOGY
Publication Type: Journal Article
Abstract: Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where > 90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative. Resistant populations of Plasmodium falciparum were selected extremely rapidly in Southeast Asia and South America. If this happens in sub-Saharan Africa, it will be a public health disaster because no inexpensive alternative is currently available. This article reviews the molecular mechanisms of this resistance and discusses how to extend the therapeutic life of antifolate drugs.
Publisher: ELSEVIER SCI LTD
Keywords: REDUCTASE-THYMIDYLATE SYNTHASE; HUMAN MALARIA PARASITE; DIHYDROPTEROATE SYNTHETASE GENES; IN-VIVO RESISTANCE; DIHYDROFOLATE-REDUCTASE; DRUG-RESISTANCE; CHLORPROGUANIL-DAPSONE; CHLOROQUINE RESISTANCE; SELECTIVE PRESSURE; SEQUENCE-ANALYSIS
Publisher's Version: https://doi.org/10.1016/S1471-4922(01)02085-2
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2001-12-01 12:00:00