L-MYC AND N-MYC INFLUENCE LINEAGE DETERMINATION IN THE CENTRAL-NERVOUS-SYSTEM
- Author(s)
- Bernard, O; DRAGO, J; SHENG, H;
- Details
- Publication Year 1992-12,Volume 9,Issue #6,Page 1217-1224
- Journal Title
- NEURON
- Publication Type
- Journal Article
- Abstract
- The N-myc and the L-myc proto-oncogenes are expressed during embryonal development mainly in the developing brain. Studies of their expression in single neuroepithelial cells revealed that neural precursors not yet committed to the glial or the neuronal lineage expressed both genes, but after lineage commitment they expressed either N-myc or L-myc. Moreover, enforced expression of L-mycin the neural precursor cell line 2.3D caused neuronal differentiation, while the expression of N-myc promoted glial differentiation. These results indicate that L-myc and N-myc play critical roles in lineage determination for the central nervous system.
- Publisher
- CELL PRESS
- Keywords
- DNA-BINDING; TRANSCRIPTIONAL REGULATION; LEUCINE ZIPPER; C-MYC; GENE; EXPRESSION; MURINE; DIMERIZATION; ONCOGENES; IMMORTALIZATION
- Publisher's Version
- https://doi.org/10.1016/0896-6273(92)90079-S
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1992-12-01 12:00:00