NUCLEOTIDE-SEQUENCE OF BUP, AN UPSTREAM GENE IN THE BMI-1 PROVIRAL INSERTION LOCUS
- Details
- Publication Year 1992-11,Volume 17,Issue #1,Page 17-20
- Journal Title
- MOLECULAR BIOLOGY REPORTS
- Publication Type
- Journal Article
- Abstract
- The ability of Moloney murine leukemia virus to accelerate lymphomagenesis in Emu-myc transgenic mice is frequently associated with proviral integration within a locus denoted bmi-1. This locus contains not only the bmi-1 gene implicated as a collaborator with myc in lymphomagenesis but also just upstream an unknown gene denoted bup. The nucleotide sequence reported here for bup cDNA and flanking genomic sequences reveals that this widely expressed gene comprises at least 7 exons and potentially encodes a polypeptide of 195 amino acid residues. Computer searches with this polypeptide sequence revealed no close homolog in the databases, nor any conserved motifs, and it is unrelated to the product of the mel-13 gene, which lies just upstream from the bmi-1 homolog mel-18.
- Publisher
- KLUWER ACADEMIC PUBL
- Keywords
- MYC TRANSGENIC MICE; C-MYC; LYMPHOMAGENESIS; ONCOGENES
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1992-11-01 12:00:00