E-MU-BCL-2 TRANSGENE FACILITATES SPONTANEOUS TRANSFORMATION OF EARLY PRE-B AND IMMUNOGLOBULIN-SECRETING CELLS BUT NOT T-CELLS
- Author(s)
- Strasser, A; Harris, AW; Cory, S;
- Details
- Publication Year 1993-01,Volume 8,Issue #1,Page 1-9
- Journal Title
- ONCOGENE
- Publication Type
- Journal Article
- Abstract
- To assess the lymphoid tumorigenic potential of bcl-2, mice of five independent strains expressing a bcl-2 transgene in B and/or T cells were monitored for disease up to 12 months of age. Lymphoma prevalence was minimal in the T lineage but significant, although low (3-15%), in the B lineage. The principal types of tumors were plasmacytomas secreting immunoglobulin and novel lymphomas that expressed markers such as Sca-1, CD4, Thy-1, CD34 and CD45(B220), consistent with an origin very early in B-lymphoid development. Rearrangement of the c-myc gene was common in the plasmacytomas, implying a synergistic role for myc and bcl-2 in their etiology, but was not detected in the lymphomas.
- Publisher
- STOCKTON PRESS
- Keywords
- CHRONIC LYMPHOCYTIC-LEUKEMIA; LIGHT CHAIN GENE; HUMAN FOLLICULAR LYMPHOMA; C-MYC ONCOGENE; BCL-2 GENE; CHROMOSOME-TRANSLOCATION; VARIANT TRANSLOCATION; MEMBRANE PROTEIN; ACTIVATION; EXPRESSION
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Creation Date: 1993-01-01 12:00:00