CELLULAR ASPECTS OF EARLY T-CELL DEVELOPMENT
- Author(s)
- Shortman, K;
- Details
- Publication Year 1992-04,Volume 4,Issue #2,Page 140-146
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Although the nature of the precursor cells seeding the thymus is still uncertain, their immediate progeny in the adult murine thymus have now been isolated. These lymphoid-restricted, prothymocyte-like cells express CD4, but neither CD4 nor CD8 seem to be involved in the early steps of T-cell development. Cytokines produced by stromal cells are likely to be involved in intrathymic T-cell development, but interleukin-2 and interleukin-4 do not appear to be required. There is still no satisfactory cell-culture model of intrathymic T-cell development. Current culture systems reflect only fragments of the process, or are models of extrathymic developmental pathways.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- PROGENY
- Publisher's Version
- https://doi.org/10.1016/0952-7915(92)90003-W
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1992-04-01 12:00:00