INFLAMMATION BUT NOT AUTOIMMUNITY OCCURS IN TRANSGENIC MICE EXPRESSING CONSTITUTIVE LEVELS OF INTERLEUKIN-2 IN ISLET BETA-CELLS
- Author(s)
- Allison, J; MALCOLM, L; CHOSICH, N; Miller, JFAP;
- Details
- Publication Year 1992-05,Volume 22,Issue #5,Page 1115-1121
- Journal Title
- EUROPEAN JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Transgenic mice expressing murine interleukin (IL)-2 constitutively in islet beta-cells were generated (RIP-IL-2 mice). They died at an early age, when higher levels of IL-2 were produced, because of a predominant macrophage inflammatory response that destroyed the exocrine pancreas. Animals with lower levels of IL-2 survived and had islets that became increasingly infiltrated with lymphocytes over time. However, in spite of the presence of impressive peri- and intra-islet infiltrates, autoimmunity to islet antigens was not seen. Autoimmunity was also not induced to extrathymic H-2K(b) molecules known to induce tolerance by a peripheral mechanism when the RIP-IL-2 mice were mated to other mice expressing H-2K(b) in islet beta-cells (RIP-K(b)) mice). Apparently, IL-2 can act only on activated T cells and is unable to reverse tolerance in T cells that have been made unresponsive through inappropriate presentation of antigen.
- Publisher
- VCH PUBLISHERS INC
- Keywords
- INTERFERON-GAMMA; RECEPTOR EXPRESSION; THYMECTOMIZED MICE; CLONAL ANERGY; NUDE-MICE; TOLERANCE; ANTIGEN; THYMUS; UNRESPONSIVENESS; LYMPHOCYTES
- Publisher's Version
- https://doi.org/10.1002/eji.1830220503
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1992-05-01 12:00:00