HEMATOLOGIC DISEASE INDUCED IN BALB/C MICE BY A BCR-ABL RETROVIRUS IS INFLUENCED BY THE INFECTION CONDITIONS
- Author(s)
- Elefanty, AG; Cory, S;
- Details
- Publication Year 1992-04,Volume 12,Issue #4,Page 1755-1763
- Journal Title
- MOLECULAR AND CELLULAR BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Irradiated mice reconstituted with bone marrow cells infected with a retrovirus carrying the bcr-abl oncogene of human chronic myeloid leukemia are subject to a range of neoplastic hematopoietic diseases, both myeloid and lymphoid. Comparison of DBA/2 and C57BL/6 mice has revealed a marked strain difference in susceptibility to the various tumor types. The present study, performed with BALB/c mice, indicates that the kinetics and nature of the induced disease can be modulated by the infection procedure, as well as the genetic background, and that retroviral regulatory sequences may influence the outcome. A distinctive clonal myeloproliferative disorder, somewhat akin to chronic myeloid leukemia but with prominent erythroid and mast cell components, as well as granulocytic excess, was characterized.
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- MYELOPROLIFERATIVE SARCOMA-VIRUS; CHRONIC MYELOGENOUS LEUKEMIA; CHRONIC GRANULOCYTIC LEUKEMIA; HEMATOPOIETIC STEM-CELLS; LONG TERMINAL REPEAT; TRANSGENIC MICE; PHILADELPHIA-CHROMOSOME; V-ABL; ONCOGENE; MURINE
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1992-04-01 12:00:00