CYCLOPHILIN OF SCHISTOSOMA-JAPONICUM
Details
Publication Year 1992-08,Volume 78,Issue #4,Page 660-664
Journal Title
JOURNAL OF PARASITOLOGY
Publication Type
Journal Article
Abstract
A 623-bp cDNA molecule encoding cyclophilin, a specific cyclosporin A-binding protein, has been isolated from Schistosoma japonicum using a heterologous cDNA probe from Echinococcus granulosus. The nucleotide sequence of this molecule has been determined. and the deduced amino acid sequence has revealed extensive homology with homologues of other species. Southern blot analysis suggests that S. japonicum cyclophilin is the product of a single-copy gene. The cloning of this cDNA will allow an investigation of cyclophilin as a possible target of the antischistosome effects of cyclosporin A.
Publisher
AMER SOC PARASITOLOGISTS
Keywords
CIS-TRANS ISOMERASE; A-BINDING PROTEIN; AMINO-ACID SEQUENCE; CYCLOSPORIN-A; PROLYL ISOMERASE; MANSONI; DNA; MICE; SUSCEPTIBILITY; FRAGMENTS
Publisher's Version
https://doi.org/10.2307/3283541
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 1992-08-01 12:00:00
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