REGULATION OF TCR-ALPHA AND TCR-BETA GENE ALLELIC EXCLUSION DURING T-CELL DEVELOPMENT
- Author(s)
- Malissen, M; TRUCY, J; JOUVINMARCHE, E; CAZENAVE, PA; Scollay, R; Malissen, B;
- Details
- Publication Year 1992-08,Volume 13,Issue #8,Page 315-322
- Journal Title
- IMMUNOLOGY TODAY
- Publication Type
- Journal Article
- Abstract
- Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha-beta-combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta-genes in mature T-cell lines and TCR alpha-beta-transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with two productive alpha-gene rearrangements.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- RECEPTOR TRANSGENIC MICE; PRE-B CELLS; V-ALPHA; IMMUNOGLOBULIN GENE; ANTIGEN RECEPTOR; CHAIN GENE; V(D)J RECOMBINATION; SURFACE EXPRESSION; MESSENGER-RNA; REARRANGEMENT
- Publisher's Version
- https://doi.org/10.1016/0167-5699(92)90044-8
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1992-08-01 12:00:00