SCL AND RELATED HEMATOPOIETIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS
- Author(s)
- Green, AR; Begley, CG;
- Details
- Publication Year 1992-09,Volume 10,Issue #5,Page 269-276
- Journal Title
- INTERNATIONAL JOURNAL OF CELL CLONING
- Publication Type
- Journal Article
- Abstract
- The helix-loop-helix (HLH) proteins are a family of transcription factors that include proteins critical to differentiation and development in species ranging from plants to mammals. Five members of this family (MYC, SCL, TAL-2, LYL-1 and E2A) are implicated in oncogenic events in human lymphoid tumors because of their consistent involvement in chromosomal translocations. Although activated in T cell leukemias, expression of SCL and LYL-1 is low or undetectable in normal T cell populations. SCL is expressed in erythroid, megakaryocyte and mast cell populations (the same cell lineages as GATA-1, a zinc-finger transcription factor). In addition, both SCL and GATA-1 undergo coordinate modulation during chemically induced erythroid differentiation of mouse erythroleukemia cells and are down-modulated during myeloid differentiation of human K562 cells, thus implying a role for SCL in erythroid differentiation events. However, in contrast to GATA-1, SCL is expressed in the developing brain. Studies of the function of SCL suggest it is also important in proliferation and self-renewal events in erythroid cells.
- Publisher
- ALPHAMED PRESS
- Keywords
- T-CELL LEUKEMIA; DNA-BINDING MOTIF; CHROMOSOMAL TRANSLOCATION; MURINE HOMOLOG; MESSENGER-RNA; TAL-1 GENE; PRE-B; PROTEIN; MYC; DIFFERENTIATION
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Creation Date: 1992-09-01 12:00:00