ISLET CELL ANTIGENS IN INSULIN-DEPENDENT DIABETES - PANDORA BOX REVISITED
- Author(s)
- Harrison, LC;
- Details
- Publication Year 1992-09,Volume 13,Issue #9,Page 348-352
- Journal Title
- IMMUNOLOGY TODAY
- Publication Type
- Journal Article
- Abstract
- A major goal of research into IDDM has been the identification of the 'causative antigen'. As described in this article by Len Harrison, this reductionist aim is confounded by the fact that numerous candidate islet cell antigens have been described. He scrutinizes the credentials of these candidates and discusses the problem of using autoantibodies to identify causative antigens in a T-cell-mediated disease.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- GLUTAMIC-ACID DECARBOXYLASE; PANCREATIC BETA-CELLS; ANTIBODIES; MELLITUS; AUTOANTIGEN; PROTEINS; CLONING; BRAIN; AUTOANTIBODIES; EXPRESSION
- Publisher's Version
- https://doi.org/10.1016/0167-5699(92)90170-C
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1992-09-01 12:00:00