INCREASED LEVELS OF LEUKEMIA INHIBITORY FACTOR IN SYNOVIAL-FLUID FROM PATIENTS WITH RHEUMATOID-ARTHRITIS AND OTHER INFLAMMATORY ARTHRITIDES
- Author(s)
- Waring, PM; Carroll, GJ; KANDIAH, DA; BUIRSKI, G; Metcalf, D;
- Details
- Publication Year 1993-07,Volume 36,Issue #7,Page 911-915
- Journal Title
- ARTHRITIS AND RHEUMATISM
- Publication Type
- Journal Article
- Abstract
- Objective. To examine svnovial fluid (SF) from patients with arthritis, for the presence of the cytokine leukemia inhibitory factor (LIF). Methods. SF from 152 subjects was examined for LIF, using a radioreceptor competition assay. Results. LIF was present at concentrations of 1-43 ng/ml in the SF of 23% of patients with rheumatoid arthritis (RA) or other inflammatory or infectious arthritides but in only 1 of 29 patients with osteoarthritis (P < 0.01). In the RA patients, the SF LIF concentration correlated significantly with the peripheral blood white blood cell count (WBC) (P < 0.05) and the SF WBC count (P < 0.01), but not with other clinical or radiologic parameters of disease activity or progression. Conclusion. LIF is implicated as a potential mediator of the local or systemic inflammatory response or the joint destruction seen in inflammatory arthritis.
- Publisher
- LIPPINCOTT-RAVEN PUBL
- Keywords
- DIFFERENTIATION-INDUCING FACTOR; FACTOR LIF; CELLS; MICE
- Publisher's Version
- https://doi.org/10.1002/art.1780360707
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1993-07-01 12:00:00