FAILURE OF A PROTECTIVE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MOLECULE TO DELETE AUTOREACTIVE T-CELLS IN AUTOIMMUNE DIABETES
- Author(s)
- Slattery, RM; Miller, JFAP; Heath, WR; Charlton, B;
- Details
- Publication Year 1993-11-15,Volume 90,Issue #22,Page 10808-10810
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Publication Type
- Journal Article
- Abstract
- The association of major histocompatibility complex genes with autoimmune diseases is firmly established, but the mechanisms by which these genes confer resistance or susceptibility remain controversial. The controversy extends to the nonobese diabetic (NOD) mouse that develops disease similar to human insulin-dependent diabetes mellitus. The transgenic incorporation of certain class II major histocompatibility complex genes protects NOD mice from diabetes, and clonal deletion or functional silencing of autoreactive T cells has been proposed as the mechanism by which these molecules provide protection. We show that neither thymic deletion nor anergy of autoreactive T cells occurs in NOD mice transgenic for I-A(k). Autoreactive T cells are present, functional, and can transfer diabetes to appropriate NOD-recipient mice.
- Publisher
- NATL ACAD SCIENCES
- Keywords
- A BETA-CHAIN; NOD MICE; PREVENTION; TOLERANCE; MELLITUS; REACTIVITY; INSULITIS; THYMUS; UNIQUE; MOUSE
- Publisher's Version
- https://doi.org/10.1073/pnas.90.22.10808
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1993-11-15 12:00:00