GENETIC-BASIS FOR DIABETES RESISTANCE IN NOD WEHI MICE
- Author(s)
- Baxter, AG; HAMILTON, F; Mandel, TE; Augustine, C; Cooke, A; Morahan, G;
- Details
- Publication Year 1993-10,Volume 20,Issue #5,Page 409-417
- Journal Title
- EUROPEAN JOURNAL OF IMMUNOGENETICS
- Publication Type
- Journal Article
- Abstract
- The basis for diabetes resistance in low diabetes incidence NOD/Wehi mice was examined in a breeding study. NOD/Wehi mice were crossed with high diabetes incidence NOD/Lt mice producing F1 hybrid mice which expressed a low incidence of diabetes. To distinguish between genetic and environmental causes for diabetes resistance, these F1 mice were backcrossed to NOD/Lt mice resulting in BC1 hybrid mice which expressed an intermediate incidence of diabetes. Similar results were obtained by examining the severity of insulitis in the hybrid mice. As both the incidence of diabetes and severity of insulitis in the hybrid mice were consistent with a single dominant gene mediating diabetes resistance, an attempt to localize this gene was made. Although over 140 loci which display polymorphism amongst inbred strains were typed in both parental lines, only a single locus, D8Mit9, was found to differ. As heterozygotes at D8Mit9 were not over represented amongst 45 diabetic BC1 hybrid mice examined, it was concluded that a resistance gene was not linked to this locus.
- Publisher
- BLACKWELL SCIENCE LTD
- Keywords
- MOUSE CHROMOSOME-1; RECEPTOR GENES; LINKAGE MAP; LOCALIZATION; CYCLOPHOSPHAMIDE; DIVERSITY; ONCOGENE; MELLITUS; CLONE; LOCUS
- Publisher's Version
- https://doi.org/10.1111/j.1744-313X.1993.tb00160.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1993-10-01 12:00:00